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The anti-corruption campaigner fell ill during a flight and the plane made an emergency landing in Omsk, Kira Yarmysh said, adding that they suspected something had been mixed into his tea.
The hospital said Mr Navalny was in a stable but serious condition.
Mr Navalny, 44, is a staunch critic of President Vladimir Putin.
In June he described a vote on constitutional reforms as a "coup" and a "violation of the constitution".
The reforms allow Mr Putin to serve another two terms in office.
What has the spokeswoman said?
Kira Yarmysh, the press secretary for the Anti-Corruption Foundation, which Mr Navalny founded in 2011, tweeted: "This morning Navalny was returning to Moscow from Tomsk. "During the flight, he felt ill. The plane made an urgent landing in Omsk. Alexei has toxic poisoning. Right now we are going to hospital." She added: "We suspect that Alexei was poisoned by something mixed into [his] tea. It was the only thing he drank since morning. "Doctors are saying that the toxic agent absorbed faster through the hot liquid. Right now Alexei is unconscious." tMs Yarmysh later tweeted that Mr Navalny was in intensive care, on a ventilator and in a coma. She said doctors were initially ready to share any information but were now saying the toxicology tests were delayed and were "clearly playing for time, and not saying what they know". The hospital was now full of police officers,
He made a name for himself by exposing official corruption, labelling Mr Putin's United Russia as "the party of crooks and thieves", and has served several jail terms.
In 2011 he was arrested and imprisoned for 15 days following protests over vote-rigging by Mr Putin's United Russia party in parliamentary elections.
Mr Navalny was briefly jailed in July 2013 on embezzlement charges but denounced the sentence as political.
He attempted to stand in the 2018 presidential race but was barred because of previous fraud convictions in a case he again said was politically motivated.
He attempted to stand in the 2018 presidential race but was barred because of previous fraud convictions in a case he again said was politically motivated.
Mr Navalny was also given a 30-day jail term in July 2019 after calling for unauthorised protests.
He was taken ill during that jail sentence. Doctors diagnosed him with "contact dermatitis" but he said he had never had any acute allergic reactions and his own doctor suggested he might have been exposed to "some toxic agent"
. Mr Navalny also said he thought he may have been poisoned.
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